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Much of the research on CBD and THC is preclinical, meaning it’s been studied in animal models. Large-scale human trials are necessary to determine if CBD or THC can help treat most of these conditions. Though it does act on cannabinoid receptors, CBD mainly affects other receptors, including serotonin receptors. It may help counteract some of the negative effects of THC, including serious side effects like psychosis. CBD has many purported therapeutic properties. Pain. Overall, there isn’t enough evidence that CBD by itself helps with pain. Some research has shown that high doses can improve neuropathy (nerve pain), though more data is necessary. Anxiety. So far, the results are mixed. Some studies show that CBD can improve symptoms of social anxiety disorder and post-traumatic stress disorder (PTSD), while others show no effect. Seizures. Epidiolex, a purified CBD oil, is approved by the Food and  [[https://www.ebersbach.org/index.php?title=User:DavisSinnett|Highline Wellness CBD official site]] Drug Administration (FDA) for some hard-to-treat types of childhood epilepsy.



Brain protection. Animal studies have shown that CBD may have benefits for those who have Alzheimer’s disease or Parkinson’s disease, but human clinical trials are necessary to verify these effects. Effects on animals may or may not translate into benefits for humans. THC is the psychoactive ingredient from the marijuana plant. The possession and use of marijuana and THC-containing products are not legal in all U.S. THC is effective for increasing appetite and for nausea and vomiting related to cancer chemotherapy. Pain. Prescription THC products have been shown to improve neuropathy and quality of life. Spasticity (muscle tightness). Sativex (nabiximols), a mouth spray that combines THC and CBD, is approved for spasticity in Europe. PTSD. A very small trial found that Cesamet reduced nightmares in 10 military personnel with PTSD. Irritable bowel syndrome (IBS). Smoking THC was found to improve symptoms of IBS, but benefits may be only short-lived. People who used THC long-term were more likely to ultimately require surgery for IBS.